A team of researchers from University of Illinois has solved the mystery of how a protein associated with the HIV virus can cross cell membranes. Their findings could improve the design of therapeutic agents that cross a variety of such membranes.
The TAT protein transduction domain of the HIV virus is a tiny part of the overall TAT protein (containing only 11 amino acids), but it can slip across lipid-rich membranes that are designed to keep things out. Although it is not involved in transmitting HIV, TAT aids the passage of other materials across the membranes of infected cells.
Research has pointed to one of its amino acids called arginine, as the one responsible for the activity. They explained that most membranes are composed of a double layer of neutral, water-repellent lipids on their interiors with hydrophilic (water-loving) "head groups" on their internal and external surfaces.
The head groups generally carry a mildly negative charge, and can attract positively-charged arginine. This results to the deformation of the membrane, making it porous (or having lots of holes) in the process. However, when researchers replaced arginine with other positively-charged amino acids, it lost its function.
Researchers hope these findings will aid further studies in enhancing the properties of the TAT protein that make it a good vehicles for transporting therapeutic molecules into cells.
Posted in
This post is going to give you some suggestions that I am sure will help you a lot.
I’d just like to let u know how much I learnt from reading blogs Bookmarked you.Hope to be back fast for some more goodies
I would just like to let u know how much I learnt from reading articles Tweeted u.Hope 2 be back fast for some more good stuff
I’d just like to tell you how much I learnt from reading website Favorited it.Hope to be back again for some more good articles
I would just like to let u know how much I learnt from reading writtings Tweeted u.Hope 2 be back soon for some more good articles
Hello dude, you have an excellent web site. I love it. And I feel numerous individuals will adore too. Why not strive more challenging to optimize your site, so it might be less complicated to find this weblog in search engine. I will not know how to, but I know you are able to do slightly tweak with your site to have a greater position. A lot of individuals will thanks on your good info. Great position!
This really is the initially time I pay a visit to a blog with comprehensive info and no abuse. Thank you for sharing your expertise right here. Please maintain update it, I imagine a lot of people will appreciate your web page and say thank. Hold on your track, guys!
Cool webpage liked u thanks
The next time I read a blog, I hope that it doesnt disappoint me as much as this one. I mean, I know it was my choice to read, but I actually thought youd have something interesting to say. All I hear is a bunch of whining about something that you could fix if you werent too busy looking for attention.
informative post. I really liked it.
Me too, ty for posting this..
Seeing that i have been on the lookout temporarly for finding a good quality content articles with regard to this unique issue . Searching in Google I now stumbled upon this website. Reading this post So i am truly satisfied to imply that I get a positive feeling I found everything that I was ready for. Most definitely i’ll ensure to remember this blog and visit on a constant basis.
I have been browsing for a time for one good view that is related to this area . Scouting in Bing I finally observed this page. Reading this data I’m just thrilled to imply that I have a fine sense I stumbled onto everything that I was looking for. Most definitely i’ll make certain to remember this site and visit constantly.
I have been scouting for a short time to get a beneficial study on the subject of this kind of idea . Looking around in Yahoo and google I at last picked up this web site. Looking at this kind of review So i’m seriously happy to say that I get a positive uncanny feeling I stumbled upon just what I wanted. I’ll make certain to remember this web site and take a look on a constant basis.
Seeing that i have been researching for a short time for just a great content articles focused on the following subject matter . Looking in Aol I now found out this website. Looking at this data I’m truly satisfied to convey that I get a good uncanny feeling I stumbled onto exactly what I needed. I most certainly will make sure to remember this website and take a visit constantly.
Thank you for sharing this information, I would recommend it to my friends, and hopefully this article useful to those who read it. thanks.
I am attempting to read your blog on my iphone 3gs, but its not working for some reason. Can you let me and other readers know what we have to do to go through it by way of this type of device.
hi webmaster, your them know how best to get the rank from google. one is to increase the link popularity, how to improve link popularity? one of the ways of the many ways is to multiply the link partners with other sites.
Aloha! I discovered this webpage by chance, I was searching Yahoo for black friday 2010 when I found your website. I’m lucky I found it. Just what I was searching for. Bookmarked your page, be back in a day or two
to attract the visitors to the site is a popular conten, the easiest way to find out what topics are popular to use google trends to find out. In my article on this blog page is quite popular and many are looking for him.
hi webmaster, your them know how best to get the rank from google. one is to increase the link popularity, how to improve link popularity? one of the ways of the many ways is to multiply the link partners with other sites.
These are some great points!
I’m getting a browser error, is anyone else?
You are a very smart person!
Very good written post. It will be useful to anybody who usess it, as well as yours truly
. Keep up the good work – looking forward to more posts.
Came by to lear from this once again…… and add it to my bookmarks!
It’s a great post. Thanks and continue sharing.Casino game
This is something I was looking for, thanks for posting
It is truely interesting post, but I do not see everything completely clear, especially for someone not involved in that topic. Anyway very interesting to me.
I found your entry interesting do I’ve added a Trackback to it on my weblog
……
If you’re still on the fence: grab your favorite earphones, head down to a Best Buy and ask to plug them into a Zune then an iPod and see which one sounds better to you, and which interface makes you smile more. Then you’ll know which is right for you.
One might as well be hanged for a sheep as a lamb.
people may disagree with a person who posted it, but I am thankful for it.
Hey friends. I really like this blog. I found here usefull info. Thanks
I have developed a blog and and i want to change the theme.I got some ideas from here! You could visit my website and tell me your opinion!
Your blog is fine. I just want to comment on the design. Its too loud. Its doing way too much and it takes away from what youve got to say –wch I think is really important. I don’t know if you didnt suppose that your words could hold everyones attention, but you were wrong.
I just added this site to my feed reader, great stuff. Can’t get enough!
Best talk here cheap clothing idear,do at home, clothing wholesaleris one way to ,nice post here cheap chi flat iron .should do any cheap designer handbags,I like the fastion clothes at clothing store;
Very interesting article. It helps me a lot.Parier en ligne
I’m impressed, I must say. Really seldom do I encounter a blog that’s both educative and entertaining, and let me tell you, you have hit the nail on the head. Your idea is outstanding; the matter is something that not many people are speaking intelligently about. I am very happy that I stumbled across this in my search for something relating to it.
Thanks bud. Not bad submissions you got going on here. Have some more websites to point to with a bit more stuff like this?
I am impressed, I have to say. Really seldom do I encounter a blog that is both informative and entertaining, and let me tell you, you’ve hit the nail on the head. Your article is important; the issue is something that not enough people are speaking intelligently about. I am really happy that I stumbled across this in my search for something relating to it.
After read a couple of the articles on your site these few days, and I really like your style of blogging. I tag it to my bookmark website list and will be checking back soon. Please check out my internet site as well and let me know what you think.
Man! It’s like you read my mind! You seem to know so much about this, like you wrote the book in it or something. I think that you could do with some pictures to drive the message home a bit, besides that, this is wonderful blog. A good read. I’ll definitely be back.
Hello My name is Jamie ,I am a tea lover, enjoy the smell & the taste of tea as the first thing after waking up. I sip minimum eight glasses every day. BTW nice blog, Hope you have a good day.
You deserve credit for all the work you put in to this post, keep up the good work.
Acai Berry is really a great option for the weight losers and the people across the world are trying to get various ways to get fit and maintain their fitness.
I have tried numerous times to quit smoking. I have smoked about a pack per day for 29 years. Though the electronic cigarette is not a smoking cessation device, I have cut my consumption of cigarettes to about 3 per day, comfortably. While it’s true that I am currently addicted to nicotine, no other nicotine replacement therapy has worked for me. I feel better, I breathe better, I smell better. The vapor produced by my e-cigarette device does not output an offensive smell. I feel better knowing that I am not imposing on people around me. For me the electronic cigarette has truly been a miracle.
Have you ever thought about adding a little bit more than just your thoughts? I mean, what you say is important and everything. But its got no punch, no pop! Maybe if you added a pic or two, a video? You could have such a more powerful blog if you let people SEE what youre talking about instead of just reading it.
I’m happy I found this blog, I couldnt discover any info on this subject matter prior to. I also run a site and if you want to ever serious in a little bit of guest writing for me if possible feel free to let me know, i’/m always look for people to check out my site. Please stop by and leave a comment sometime!